The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS‐CoV2 Infection
We show that SARS-CoV2 infections drive a VWF/ADAMTS13 axis imbalance, inducing an increase in tPA while decreasing FIX, MMP-2, and sICAM-1 post-stroke.
Authors
- Sean Knight (ORCID: https://orcid.org/0000-0003-4773-6843)
- Graham Coutts (ORCID: https://orcid.org/0000-0002-5865-9495)
- Siew Yan Wong (ORCID: https://orcid.org/0000-0001-5785-6772)
- Ioana‐Emilia Mosneag (ORCID: https://orcid.org/0000-0003-0993-8583)
- E Collins
- Barry W. McColl (ORCID: https://orcid.org/0000-0002-0521-9656)
- John R. Grainger (ORCID: https://orcid.org/0000-0002-4052-5923)
- Rachel Bronwen Jones (ORCID: https://orcid.org/0000-0003-4790-283X)
- Amanda J. Unsworth (ORCID: https://orcid.org/0000-0003-3809-5984)
- Laura McCulloch (ORCID: https://orcid.org/0000-0002-1396-6643)
- Nadim Luka (ORCID: https://orcid.org/0009-0009-7912-835X)
- Mehwish Younas (ORCID: https://orcid.org/0000-0002-3054-1997)
- Kieron South (ORCID: https://orcid.org/0000-0002-9141-3438)
- Craig P. Smith (ORCID: https://orcid.org/0000-0002-4828-2700)
- Stuart M. Allan
- Amy Bradley
- C. Quigley
Institutions
- University of Leeds (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- UK Dementia Research Institute (GB)
- Centre for Inflammation Research (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/brb3.70348
- Citations
- 3
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- British Heart Foundation
- Medical Research Council