ROLE OF RETURBT IN TA BLADDER TUMOURS OUR EXPERIENCE IN TERTIARY HEALTH CARE.

Background: Bladder cancer is one of the most frequently diagnosed malignancies of the urinary tract, with non-muscle invasive bladder cancer (NMIBC) constituting nearly 75% of all cases. Among these, Ta bladder tumors represent a subset confined to the urothelium without lamina propria invasion. While transurethral resection of bladder tumor (TURBT) is the primary diagnostic and therapeutic modality, studies indicate a substantial risk of residual tumor presence after initial resection. Re-TURBT (repeat TURBT) has been advocated to ensure complete tumor removal, improve staging accuracy, and reduce recurrence rates. However, its necessity in Ta tumors remains a topic of debate, particularly in resource-limited settings.  Aim:  This study aims to evaluate the role of re-TURBT in Ta bladder tumors at Hamdard Institute Of Medical Sciences, New Delhi , by analyzing its impact on residual tumor detection, pathological upstaging, recurrence rates, and treatment modifications.   Methods:  A prospective study was conducted in the department of surgery at Hamdard Institute Of Medical Sciences, New Delhi from Dec 2023 to Jan 2025. A total of 120 patients with newly diagnosed Ta bladder tumors were included. All patients underwent an initial TURBT, followed by a scheduled re-TURBT within 4–6 weeks. Histopathological outcomes, presence of residual disease, upstaging rates, and recurrence patterns were analyzed. Statistical analysis was performed using SPSS software, with p-values <0.05 considered significant.   Results:  Re-TURBT identified residual tumor in 38% of cases, with 12% demonstrating pathological upstaging to T1. The recurrence rate at 12 months was 24% in the re-TURBT group compared to 41% in patients who did not undergo repeat resection. No significant increase in perioperative complications was noted. These findings suggest that re-TURBT contributes to better disease control and risk stratification in Ta bladder tumors.   Conclusion:   Re-TURBT plays a crucial role in the management of Ta bladder tumors, significantly reducing recurrence and enabling more accurate staging. These results support the integration of re-TURBT into routine NMIBC management, particularly in cases with high-risk features. Further long-term studies are needed to assess its impact on overall survival and disease progression.  

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Publication Details

Published
2025-02-20
DOI
https://doi.org/10.53555/5wwrkc44
Primary Topic
Bladder and Urothelial Cancer Treatments
Type
article
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article

ROLE OF RETURBT IN TA BLADDER TUMOURS OUR EXPERIENCE IN TERTIARY HEALTH CARE.

Yasir Iqbal Lone
Bladder and Urothelial Cancer Treatments
article

ROLE OF RETURBT IN TA BLADDER TUMOURS OUR EXPERIENCE IN TERTIARY HEALTH CARE.

Yasir Iqbal Lone
article en

Abstract

Background: Bladder cancer is one of the most frequently diagnosed malignancies of the urinary tract, with non-muscle invasive bladder cancer (NMIBC) constituting nearly 75% of all cases. Among these, Ta bladder tumors represent a subset confined to the urothelium without lamina propria invasion. While transurethral resection of bladder tumor (TURBT) is the primary diagnostic and therapeutic modality, studies indicate a substantial risk of residual tumor presence after initial resection. Re-TURBT (repeat TURBT) has been advocated to ensure complete tumor removal, improve staging accuracy, and reduce recurrence rates. However, its necessity in Ta tumors remains a topic of debate, particularly in resource-limited settings.  Aim:  This study aims to evaluate the role of re-TURBT in Ta bladder tumors at Hamdard Institute Of Medical Sciences, New Delhi , by analyzing its impact on residual tumor detection, pathological upstaging, recurrence rates, and treatment modifications.   Methods:  A prospective study was conducted in the department of surgery at Hamdard Institute Of Medical Sciences, New Delhi from Dec 2023 to Jan 2025. A total of 120 patients with newly diagnosed Ta bladder tumors were included. All patients underwent an initial TURBT, followed by a scheduled re-TURBT within 4–6 weeks. Histopathological outcomes, presence of residual disease, upstaging rates, and recurrence patterns were analyzed. Statistical analysis was performed using SPSS software, with p-values <0.05 considered significant.   Results:  Re-TURBT identified residual tumor in 38% of cases, with 12% demonstrating pathological upstaging to T1. The recurrence rate at 12 months was 24% in the re-TURBT group compared to 41% in patients who did not undergo repeat resection. No significant increase in perioperative complications was noted. These findings suggest that re-TURBT contributes to better disease control and risk stratification in Ta bladder tumors.   Conclusion:   Re-TURBT plays a crucial role in the management of Ta bladder tumors, significantly reducing recurrence and enabling more accurate staging. These results support the integration of re-TURBT into routine NMIBC management, particularly in cases with high-risk features. Further long-term studies are needed to assess its impact on overall survival and disease progression.  

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Bladder and Urothelial Cancer Treatments
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