Toll‐like receptor 2 activation induces C‐C motif chemokine ligand 5 production in canine keratinocytes
TLR2 activation by Staphylococcus spp. may produce CCL5 in canine keratinocytes, thereby recruiting immune cells into the skin of dogs with AD. During the Th1-activated chronic phase of cAD, where TLR2 expression may be partially upregulated, Staphylococcus spp. may exacerbate skin inflammation. Further studies are warranted to determine the clinical significance and mechanisms of skin bacteria-mediated CCL5 production in keratinocytes.
Authors
- Yusuke Kaida (ORCID: https://orcid.org/0000-0003-3991-083X)
- Kaho Takahashi
- Keitaro Ohmori (ORCID: https://orcid.org/0000-0002-0582-4880)
- Takehiro Hasegawa (ORCID: https://orcid.org/0000-0002-1594-697X)
- Rina Yoshimatsu
Institutions
- Life Science Institute (JP)
- Fujita Animal Hospital (JP)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- Veterinary Dermatology
- Published
- 2025-02-19
- DOI
- https://doi.org/10.1111/vde.13330
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Japan Society for the Promotion of Science