Effects of light exposure during IVF: transcriptomic analysis of murine embryos and embryo-derived EVs
White light upregulates apoptotic pathways, at both the transcriptome and regulatory miRNAs levels. Red filtration partially counterbalances these negative effects by shifting the cellular processes towards regeneration, including DNA repair mechanisms. Extracellular vesicles of light exposed embryos play a role in blastocyst-decidua communication through the horizontal transfer of regulatory miRNAs. Our data prove that light exposure during <i>in vitro</i> fertilization modifies cell function that might affect the outcome of implantation.
Authors
- Bence Nagy (ORCID: https://orcid.org/0000-0003-3955-4863)
- Árpád Ferenc Kovács (ORCID: https://orcid.org/0000-0002-7742-160X)
- Júlia Szekeres‐Barthó (ORCID: https://orcid.org/0000-0001-7395-9667)
- Éva Pállinger (ORCID: https://orcid.org/0000-0002-5789-0951)
- Tímea Csabai
- Edit I. Buzás (ORCID: https://orcid.org/0000-0002-3744-206X)
- Nóra Fekete
- Zoltán Bognár (ORCID: https://orcid.org/0000-0001-9408-4302)
Institutions
- Semmelweis University (HU)
- Szent János Kórház (HU)
- Institute of Genetics (HU)
- University of Pecs (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1429252
- Citations
- 5
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 9.39