Facilitation of non-nociceptive bladder activity and suppression of somatic afferent inhibition by hypogastric afferents in cats
These results suggest that HGN afferents (possibly C-fiber nociceptors) from the bladder or other pelvic organs may facilitate normal bladder activity to cause bladder overactivity. Additionally, HGN afferents may influence the efficacy of tibial or pudendal neuromodulation therapy in treating OAB.
Authors
- Bing Shen (ORCID: https://orcid.org/0000-0002-0952-2257)
- Jonathan M. Beckel (ORCID: https://orcid.org/0000-0003-1390-2292)
- Changfeng Tai (ORCID: https://orcid.org/0000-0002-7776-8611)
- Jicheng Wang (ORCID: https://orcid.org/0000-0001-7740-2647)
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fnins.2025.1555152
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases