ISGylation: is our genome yearning for such a modification?
ISGylation is the post-translational modification of protein substrates covalently conjugated with the ubiquitin-like protein, interferon-stimulated gene 15 (ISG15). Although initially linked to antiviral immunity, recent evidence highlights important roles for ISGylation in various biological processes, such as maintaining genomic stability, promoting tumourigenesis, and being involved in other pathological conditions. In this review, we examine the molecular mechanisms underlying ISGylation, its interplay with other post-translational modifications, and its involvement in diverse biological and pathological processes. We propose future research directions to advance the field and discuss how ISGylation might be harnessed to ensure human health, particularly genome instability-associated diseases.
Authors
- Zhongjun Zhou (ORCID: https://orcid.org/0000-0001-7092-8128)
- Shunichi Takeda (ORCID: https://orcid.org/0000-0002-7924-7991)
- Xingzhi Xu (ORCID: https://orcid.org/0000-0002-4459-2082)
- Ying Wang (ORCID: https://orcid.org/0000-0003-2873-7197)
- Zheng Chen (ORCID: https://orcid.org/0000-0002-6582-847X)
- Zheng Li (ORCID: https://orcid.org/0000-0002-7060-2213)
- Kapanova Gulnara
- Zaure Dushimova
Institutions
- Al-Farabi Kazakh National University (KZ)
- Shenzhen University Health Science Center (CN)
- Guhua Hospital (CN)
- China Agricultural University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Acta Biochimica et Biophysica Sinica
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3724/abbs.2025028
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality