β-lapachone suppresses carcinogenesis of cervical cancer via interaction with AKT1
These findings suggest that β-lapachone inhibits the malignant progression of cervical cancer by targeting AKT1 to regulate glucose metabolism in NQO1-overexpressing cells, providing a theoretical basis for developing novel therapeutic strategies for cervical cancer.
Authors
- Yue Li (ORCID: https://orcid.org/0000-0001-7214-3463)
- Anna Han
- Jiajing Liu (ORCID: https://orcid.org/0000-0003-3268-6070)
- Pan Du (ORCID: https://orcid.org/0000-0001-7335-4078)
- Mengying Wang (ORCID: https://orcid.org/0000-0001-7591-522X)
- Yingshi Piao (ORCID: https://orcid.org/0000-0002-7466-1595)
- Liyan Chen
Institutions
- Yanbian University (CN)
- State Ethnic Affairs Commission (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fphar.2025.1509568
- Citations
- 3
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 3.92
Funders
- National Natural Science Foundation of China
- People's Government of Jilin Province
- Department of Science and Technology of Jilin Province