Aclacinomycin enhances the killing effect of allogeneic NK cells on acute myeloid leukemia cells by inducing immunogenic cell death

These results demonstrated that allogeneic NK cells had enhanced functional responses when stimulated with ACM <i>in vitro</i>, exhibiting superior effector cytokine production and cytotoxicity compared to the control, which contained conventional NK cells. In conclusion, the present study suggested that the combination of ACM and allogeneic NK cells is a promising therapeutic strategy against AML.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-02-20
DOI
https://doi.org/10.3389/fimmu.2025.1521939
Citations
2
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
1.59
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article

Aclacinomycin enhances the killing effect of allogeneic NK cells on acute myeloid leukemia cells by inducing immunogenic cell death

Xiaojun Xu, Yunxin Zeng, Yongbin Ye, Ning Liu et al.
2 citations
Frontiers in Immunology
Immune Cell Function and Interaction
1.59
article

Aclacinomycin enhances the killing effect of allogeneic NK cells on acute myeloid leukemia cells by inducing immunogenic cell death

Xiaojun Xu, Yunxin Zeng, Yongbin Ye, Ning Liu, Ziwen Guo, Xiaobo Wang
article en
2 citations

Abstract

These results demonstrated that allogeneic NK cells had enhanced functional responses when stimulated with ACM <i>in vitro</i>, exhibiting superior effector cytokine production and cytotoxicity compared to the control, which contained conventional NK cells. In conclusion, the present study suggested that the combination of ACM and allogeneic NK cells is a promising therapeutic strategy against AML.

Frontiers in ImmunologyVol. 16
Sun Yat-sen University (CN), The Seventh Affiliated Hospital of Sun Yat-sen University (CN), Zhongshan Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Baise University (CN), Shenzhen University Health Science Center (CN)
Good health and well-being
Openalex Percentile: Top 19%
Immune Cell Function and Interaction
1.59
DOIOpen Access PDFOpenAlex
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Aclacinomycin enhances the killing effect of allogeneic NK cells on acute myeloid leukemia cells by inducing immunogenic cell death — Xiaojun Xu, Yunxin Zeng, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS