Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules
These results suggest a role for Ets and Tcf/Lef transcription factors in the regulation of <i>Lhx2</i> expression through these limb-specific <i>Lhx2</i>-associated CRMs. Moreover, these CRMs provide a mechanism for Fgf and Wnt signaling to localize and maintain distal <i>Lhx2</i> expression during vertebrate limb development.
Authors
- Kristen L. Whitley
- Cassidy G Mulder
- Endika Haro (ORCID: https://orcid.org/0000-0002-0229-6365)
- Japhet Amoah
- J Kim
- Charmaine U. Pira
- Kerby C. Oberg (ORCID: https://orcid.org/0000-0002-1241-4273)
- José Luiz de Campos
- Karen Kennedy
- Mei Yu (ORCID: https://orcid.org/0000-0003-0306-6817)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Jessica C. Britton
- Eunyoung Kim (ORCID: https://orcid.org/0000-0002-9749-9930)
- Allen M. Cooper (ORCID: https://orcid.org/0000-0001-5673-9179)
- Billy A. Watson (ORCID: https://orcid.org/0000-0003-1896-4601)
- Ruth-Love Yeboah
- Anett Somogyi-Leatigaga
Institutions
- University of California, Irvine (US)
- Loma Linda University (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fcell.2025.1552716
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Loma Linda University
- National Institutes of Health
- National Cancer Institute
- Chao Family Comprehensive Cancer Center