Enhancing autophagy mitigates LPS-induced neuroinflammation by inhibiting microglial M1 polarization and neuronophagocytosis
Enhancing autophagy can effectively mitigate LPS-induced neuroinflammation by inhibiting microglial M1 polarization and neuronophagocytosis, thereby protecting neuronal integrity. These findings suggest potential therapeutic strategies targeting autophagy in neuroinflammatory conditions.
Authors
- Kun Ma (ORCID: https://orcid.org/0000-0002-4256-0570)
- Yun Li (ORCID: https://orcid.org/0000-0003-2040-4451)
- Guohai Su (ORCID: https://orcid.org/0000-0003-4184-4579)
- Jingjing Guo (ORCID: https://orcid.org/0000-0003-2412-8546)
Institutions
- Shandong University (CN)
- Jinan Central Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fncel.2025.1546848
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- National Natural Science Foundation of China
- Shandong First Medical University