EDN1 and NTF3 in keloid pathogenesis: computational and experimental evidence as novel diagnostic biomarkers for fibrosis and inflammation
EDN1 and NTF3, as OSRDEGs, play critical roles in the pathogenesis and progression of keloids. They may contribute to fibrosis and inflammation through the regulation of oxidative stress, the MAPK signaling pathway, and mast cell activation. These findings highlight EDN1 and NTF3 as potential diagnostic biomarkers and therapeutic targets, providing novel insights into the pathogenesis and treatment strategies for keloids.
Authors
- Hengguang Zhao
- Hongpei Zhang
- Yi Tian (ORCID: https://orcid.org/0000-0002-8233-8181)
- Nanji Chen
- Wenping Wang (ORCID: https://orcid.org/0000-0003-3667-6793)
- Bailin He (ORCID: https://orcid.org/0000-0003-3904-1945)
- Jing Liu (ORCID: https://orcid.org/0000-0003-3467-9392)
- Hui Gong
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fgene.2025.1516451
- Citations
- 3
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 6.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment