Odor induced functional connectivity alteration of POC-anterior frontal cortex-medial temporal cortex in patients with mild cognitive impairment
This study indicates that impaired FC within the primary olfactory cortex (POC)-anterior frontal cortex-medial temporal cortex circuit is a sensitive neuroimaging marker for early MCI identification. The primary dysfunction appears in the POC, suggesting that FC alterations from this region may provide novel diagnostic and therapeutic avenues for early intervention.
Authors
- Futao Chen
- Zhengge Wang
- Jiaming Lu (ORCID: https://orcid.org/0009-0001-6888-8849)
- Yajing Zhu (ORCID: https://orcid.org/0000-0002-5677-3155)
- Shuying Li (ORCID: https://orcid.org/0000-0002-6573-9733)
- Min Wu
- Xin Zhang (ORCID: https://orcid.org/0000-0002-3499-2189)
- Bing Zhang (ORCID: https://orcid.org/0000-0002-3953-0290)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Xuefeng Ma (ORCID: https://orcid.org/0000-0002-5766-759X)
- Jianan Zhou (ORCID: https://orcid.org/0000-0002-1775-6221)
- Weiping Li (ORCID: https://orcid.org/0000-0002-2352-7775)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Brain Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fnagi.2025.1502171
- Citations
- 7
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.25
Funders
- National Natural Science Foundation of China
- Nanjing University
- Graduate Research and Innovation Projects of Jiangsu Province