Scalable production of anti-inflammatory exosomes from three-dimensional cultures of canine adipose-derived mesenchymal stem cells: production, stability, bioactivity, and safety assessment
This study highlights the potential of a microcarrier-based 3D culture system for scalable cEXO production with robust anti-inflammatory activity, stability, and safety profiles. These findings advance the development of cEXO-based therapies and support their application in veterinary regenerative medicine.
Authors
- Chenphop Sawangmake (ORCID: https://orcid.org/0000-0003-2619-9487)
- Parkpoom Siriarchavatana (ORCID: https://orcid.org/0000-0002-1104-8566)
- Poorichaya Somparn (ORCID: https://orcid.org/0000-0002-7422-1135)
- Daneeya Na Nan (ORCID: https://orcid.org/0000-0001-9382-4073)
- Watchareewan Rodprasert (ORCID: https://orcid.org/0000-0002-6134-1461)
- Saranyou Oontawee (ORCID: https://orcid.org/0000-0001-6406-4124)
- Thanaphum Noom Osathanon (ORCID: https://orcid.org/0000-0003-1649-6357)
- Hiroshi Egusa (ORCID: https://orcid.org/0000-0002-0200-8132)
- Anatcha Thongsit
Institutions
- Chulalongkorn University (TH)
- Tohoku University (JP)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12917-025-04517-1
- Citations
- 8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Chulalongkorn University
- Thailand Science Research and Innovation
- Faculty of Veterinary Science, Chulalongkorn University