Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy
In patients with DN, both SIRT1 and VDR expression levels are reduced and interrelated. Low VDR expression levels could negatively affect SIRT1 transcription, thus influencing all the most pathogenetic pathways of DN regulated by this protein.
Authors
- Vincenza Spallone (ORCID: https://orcid.org/0000-0002-8905-216X)
- Paola Borgiani (ORCID: https://orcid.org/0000-0003-0859-4328)
- Cinzia Ciccacci (ORCID: https://orcid.org/0000-0002-3995-7032)
- Davide Lauro (ORCID: https://orcid.org/0000-0002-8597-4415)
- Ilenia D’Ippolito (ORCID: https://orcid.org/0000-0002-8534-7403)
- Giada De Benedittis (ORCID: https://orcid.org/0000-0001-9200-2510)
- Andrea Latini (ORCID: https://orcid.org/0000-0002-5350-7361)
- Giuseppe Novelli (ORCID: https://orcid.org/0000-0002-7781-602X)
- Beatrice Gasperini (ORCID: https://orcid.org/0000-0001-8264-6961)
- Chiara Morgante
Institutions
- University of Rome Tor Vergata (IT)
- University of Nevada, Reno (US)
- Saint Camillus International University of Health and Medical Sciences (IT)
Publication Details
- Journal
- Acta Diabetologica
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1007/s00592-025-02463-w
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Roma Tor Vergata