Russia’s first identified case of abnormal Hemoglobin Kansas with low oxygen affinity, a rare cause of cyanosis

Diagnosis of rare causes of cyanosis is if a certain difficulty. A clinical case report of cyanosis caused by the presence of abnormal Hemoglobin (Hb) Kansas with reduced oxygen affinity is presented. This is the Russia’s first detected and recorded case in a Russian child with cyanosis and mild anemia. As a result of routine examination using capillary electrophoresis and high-performance liquid chromatography, a pathological fraction of Hb was detected. Molecular genetic research according to Sanger determined a mutation in codon 102 of the β-globin gene with the replacement of aspartic acid with threonine, corresponding to rare abnormal Hb Kansas with reduced oxygen affinity.