Exploring the potential antidepressant mechanisms of ibuprofen and celecoxib based on network pharmacology and molecular docking
Ibuprofen and celecoxib primarily exert their antidepressant effects through targets and pathways related to inflammation, neural signaling, and cancer, with celecoxib showing a stronger potential antidepressant effect. The expression difference of the core target ALB between depression and healthy individuals further supports the potential effect of the drug on DD. Our findings propose new treatment strategies, support the link between inflammation and depression, and encourage reassessing existing medications for depression.
Authors
- Ranli Li
- Jia Feng (ORCID: https://orcid.org/0000-0001-9968-2360)
- Kaifang Yao (ORCID: https://orcid.org/0000-0002-4142-1835)
- Chuanjun Zhuo
- Lei Yang (ORCID: https://orcid.org/0000-0001-9498-5928)
- Chao Li (ORCID: https://orcid.org/0000-0002-0240-5170)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-4082-5026)
- Qiuyu Zhang (ORCID: https://orcid.org/0000-0002-4823-5031)
- Hongjun Tian (ORCID: https://orcid.org/0000-0002-3919-3749)
- Lina Wang (ORCID: https://orcid.org/0000-0002-5323-5431)
- Xiaoyan Ma (ORCID: https://orcid.org/0009-0007-7953-947X)
Institutions
- Tianjin Anding Hospital (CN)
- Tianjin Fourth Hospital (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.jad.2025.02.053
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00