Heteroresistance associated with the production of fosfomycin-resistant inner colonies during disk diffusion testing among a geographically diverse collection of <i>Klebsiella pneumoniae</i> clinical isolates
Production of ≥5 IC among clinical <i>K. pneumoniae</i> isolates was frequent and often resulted in an increased IC isolate MIC. Significantly greater odds of heteroresistance among IC producers were found when compared to NP isolates. Thus, presence of IC during fosfomycin DD testing should prompt avoidance of fosfomycin treatment.
Authors
- Morgan L Bixby
- Jenna Salay
- Lindsey Collins (ORCID: https://orcid.org/0009-0008-5448-9207)
- Elizabeth B. Hirsch (ORCID: https://orcid.org/0000-0002-0462-0421)
- Alexandra Bryson (ORCID: https://orcid.org/0000-0002-2957-7829)
- S.P. Oliver
- Ellora C. Daley
Institutions
- University of Minnesota (US)
- Virginia Commonwealth University (US)
- University Health System (US)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/jacamr/dlaf013
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Minnesota