The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus
Our study demonstrates that MFF-mediated mitochondrial fission inhibits insulin sensitivity and upregulates glucose transport in GDM, which is related to offspring exposure to a hyperglycemic intrauterine environment. These results provide a novel therapeutic target for addressing GDM that may mitigate unfavorable pregnancy outcomes.
Authors
- Yuanyuan Du
- Peng Gao (ORCID: https://orcid.org/0000-0002-6877-6388)
- Mengzhou He
- Caiyun Fang (ORCID: https://orcid.org/0009-0008-4809-9739)
- Lili Guo (ORCID: https://orcid.org/0000-0002-4034-6968)
- Yi Jiang (ORCID: https://orcid.org/0000-0002-6574-5949)
- Lijie Wei (ORCID: https://orcid.org/0000-0003-1693-9779)
- Shaoshuai Wang (ORCID: https://orcid.org/0000-0003-0315-7866)
- Ling Feng (ORCID: https://orcid.org/0000-0001-8833-5574)
- Xuan Zhou (ORCID: https://orcid.org/0000-0002-1345-1498)
- Rui Su (ORCID: https://orcid.org/0009-0006-5586-2048)
- Huiting Zhang (ORCID: https://orcid.org/0000-0001-5300-4679)
- Shuang Yu (ORCID: https://orcid.org/0000-0003-0918-8655)
- Shenglan Zhu
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dmso.s484002
- Citations
- 4
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China