Genomic Profiling of Extensive Stage Small-Cell Lung Cancer Patients Identifies Molecular Factors Associated with Survival
In ES-SCLC, TMB is associated with worse survival in patients treated with CT alone, and with better survival in patients treated with CT+IO, whether considered as a continuous or a dichotomized variable, at different cut-offs. Alterations in epigenetic factors are also associated to better patient prognosis.
Authors
- Giuseppe Bronte (ORCID: https://orcid.org/0000-0002-2306-2445)
- Lucio Crinò (ORCID: https://orcid.org/0000-0001-5745-6429)
- Michele Flospergher
- Paola Cravero
- Davide Angeli (ORCID: https://orcid.org/0000-0002-8855-0829)
- Milena Urbini (ORCID: https://orcid.org/0000-0002-3364-9098)
- Matteo Canale (ORCID: https://orcid.org/0000-0002-9768-7149)
- Elisabetta Petracci (ORCID: https://orcid.org/0000-0001-9456-3514)
- Mirca Valli
- Gianluca Tedaldi (ORCID: https://orcid.org/0000-0003-0540-6694)
- Giulio Rossi (ORCID: https://orcid.org/0000-0001-8855-1218)
- Chiara Bennati (ORCID: https://orcid.org/0000-0002-2970-6483)
- Riccardo Panzacchi
- Paola Ulivi (ORCID: https://orcid.org/0000-0002-4334-9662)
- Angelo Delmonte (ORCID: https://orcid.org/0000-0001-9065-6123)
- Alessandra Dubini
- Kalliopi Andrikou (ORCID: https://orcid.org/0000-0002-0572-5321)
- Ilaria Priano
- Davide Tassinari
Institutions
- Hebron University (PS)
- University of Ferrara (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale Santa Maria (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- Vall d'Hebron Hospital Universitari (ES)
- Ospedale Infermi di Rimini (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Lung Cancer Targets and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/lctt.s492825
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Roche Italia
- Ministero della Salute