eIF5A downregulated by mechanical overloading delays chondrocyte senescence and osteoarthritis by regulating the CREBBP-mediated Notch pathway
Our findings identified a crucial functional mechanism for the onset of OA, and suggest that intra-articular eIF5A injections might be a useful therapeutic strategy for OA treatment.
Authors
- Daozhang Cai (ORCID: https://orcid.org/0000-0003-2294-5411)
- Junfeng Wu
- Jia-Luo Huang (ORCID: https://orcid.org/0009-0008-5616-9661)
- Jianbin Yin (ORCID: https://orcid.org/0009-0001-9466-3635)
- Guiqing Wang (ORCID: https://orcid.org/0000-0001-6590-5394)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-3699-8672)
- Jianrong Zheng
- Rengui Lin
- Haoran Xu (ORCID: https://orcid.org/0000-0002-0213-207X)
- Jinjian Zhu
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Huizhou Central People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1302/2046-3758.142.bjr-2024-0288.r1
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.67