Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel

AskFDALabel exhibited high consistency with human AE annotation, particularly in classifying and profiling DILI and DICT. Thus, it can significantly enhance the efficiency and accuracy of AE annotation, with promising potential for advanced AE surveillance and drug safety research.

Authors

Joshua Xu (ORCID: https://orcid.org/0000-0001-5313-5847)
Weida Tong (ORCID: https://orcid.org/0000-0003-3488-6148)
Leihong Wu (ORCID: https://orcid.org/0000-0002-4093-3708)
Hong Fang (ORCID: https://orcid.org/0000-0002-2330-1469)
Yanyan Qu (ORCID: https://orcid.org/0009-0005-3094-3098)

Institutions

National Center for Toxicological Research (US)

Publication Details

Journal: Drug Safety
Published: 2025-02-20
DOI: https://doi.org/10.1007/s40264-025-01520-1
Citations: 9
Primary Topic: Computational Drug Discovery Methods
Type: article
Field-Weighted Citation Impact: 13.54

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article

Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel

Joshua Xu, Weida Tong, Leihong Wu, Hong Fang et al.

Feb 20, 2025

9 citations

Drug Safety

Computational Drug Discovery Methods

13.54

article

Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel

Joshua Xu, Weida Tong, Leihong Wu, Hong Fang, Yanyan Qu

February 20, 2025article en

9 citations

Abstract

AskFDALabel exhibited high consistency with human AE annotation, particularly in classifying and profiling DILI and DICT. Thus, it can significantly enhance the efficiency and accuracy of AE annotation, with promising potential for advanced AE surveillance and drug safety research.

Drug SafetyVol. 48(6)

National Center for Toxicological Research (US)

Openalex Percentile: Top 1%

Computational Drug Discovery Methods

13.54

DOI Open Access PDF OpenAlex

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