CDCA3-MYC positive feedback loop promotes bladder cancer progression via ENO1-mediated glycolysis
This study delineates a novel role for CDCA3 in the regulation of BLCA glycolysis and identifies its interaction with MYC as a critical positive feedback mechanism, providing fresh insights into the molecular mechanisms underlying BLCA progression.
Authors
- Dexin Shen
- Zongpan Ke (ORCID: https://orcid.org/0009-0009-4562-5833)
- Yu Liang (ORCID: https://orcid.org/0000-0003-4259-6028)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5024-0238)
- Jun Xiao (ORCID: https://orcid.org/0000-0002-4940-0174)
- Xuefeng Fan (ORCID: https://orcid.org/0000-0003-1932-725X)
- Dongmei Lu
- Xiang Yu (ORCID: https://orcid.org/0000-0002-7387-1603)
- Ping Xiang (ORCID: https://orcid.org/0000-0001-9665-4292)
Institutions
- University of Science and Technology of China (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s13046-025-03325-7
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Wuhan University
- University of Science and Technology of China