Interaction of genetic variants and methylation in transcript-level expression regulation in Alzheimer’s disease by multi-omics data analysis
Our findings especially implicate immune-related pathways as targets of these regulatory interactions. SNP-methylation interactions may thus contribute to the molecular complexity underlying immune-related pathogenies in AD patients. Our study provides a new molecular knowledge in the context of the interplay between genetic and epigenetic regulations, in that it concerns transcript expression status in AD.
Authors
- Soo-ah Cho (ORCID: https://orcid.org/0000-0002-4523-2767)
- Karen Eilbeck (ORCID: https://orcid.org/0000-0002-0831-6427)
- Woojae Choi (ORCID: https://orcid.org/0000-0002-0779-9236)
- Kwangsik Nho
- Seonggyun Han (ORCID: https://orcid.org/0000-0003-2227-4953)
- Hilary Coon (ORCID: https://orcid.org/0000-0002-8877-5446)
- Younghee Lee (ORCID: https://orcid.org/0000-0002-6850-0082)
Institutions
- Seoul National University (KR)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- National University College (PR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12864-025-11362-x
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Research Foundation
- Seoul National University
- Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University