Cover Feature: Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies (Chem. Eur. J. 11/2025)
The Cover Feature, created by Aditi Mulik from the Ruhr-Universität Bochum, illustrates a cellular tug-of-war between the design goals for cancer therapeutics of prioritizing selective targeting or increased cytotoxicity. In the associated Research Article (DOI: 10.1002/chem.202404147), N. Metzler-Nolte and co-workers explain how mitochondrial targeting allowed the less-cytotoxic compound to overcome resistance mechanisms and re-sensitized cancer cells to treatment.
Authors
- Axel Steinbrueck (ORCID: https://orcid.org/0000-0001-6014-3204)
- Aram Prokop (ORCID: https://orcid.org/0000-0003-0866-0188)
- Axel Rosenhahn (ORCID: https://orcid.org/0000-0001-9393-7190)
- Matthew L. Reback
- Christoph Rumancev (ORCID: https://orcid.org/0000-0003-0286-506X)
- Daniel Siegmund (ORCID: https://orcid.org/0000-0003-2476-8965)
- Jan Garrevoet (ORCID: https://orcid.org/0000-0001-8696-0499)
- Nils Metzler‐Nolte (ORCID: https://orcid.org/0000-0001-8111-9959)
- Gerald Falkenberg (ORCID: https://orcid.org/0000-0002-2229-1027)
Institutions
- Deutsches Elektronen-Synchrotron DESY (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Fraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT (DE)
- Helios Hospital Schwerin (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/chem.202581104
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00