In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss
This benchmarking study of commercial antibodies would be useful as a guide to screen discovery-stage biologic molecules both for drug product stability at formulation pH under storage and accelerated temperature conditions and for physiological stability under in vivo-mimicking pH and temperature stress condition.
Authors
- Dana I. Filoti (ORCID: https://orcid.org/0000-0003-0912-6657)
- Alayna George Thompson
- Rajeeva Singh (ORCID: https://orcid.org/0000-0002-1537-6209)
- Anca Clabbers (ORCID: https://orcid.org/0000-0002-4258-9680)
- Sean McCarthy (ORCID: https://orcid.org/0000-0002-5474-5388)
- Amr Ali
- Erick Mattson (ORCID: https://orcid.org/0000-0001-6612-5808)
- Jiang Zhang (ORCID: https://orcid.org/0000-0001-7392-8270)
- Richa Garg (ORCID: https://orcid.org/0000-0001-9297-1098)
- Chen Zhou (ORCID: https://orcid.org/0009-0006-8055-8339)
- Jianwen Xu
- Aimalohi Acquah
Institutions
- AbbVie (United States) (US)
- Synta Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s11095-025-03825-3
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08