DLAT activates EMT to promote HCC metastasis by regulating GLUT1-mediated aerobic glycolysis
These findings establish DLAT as a key regulator in HCC progression and suggest its potential as a promising predictive biomarker and therapeutic target for improving HCC diagnosis and treatment.
Authors
- Wei Zhuo (ORCID: https://orcid.org/0000-0002-8251-4210)
- Wei Wu (ORCID: https://orcid.org/0000-0003-0401-7363)
- Jieer Ying (ORCID: https://orcid.org/0000-0001-9452-1242)
- Qian Yin (ORCID: https://orcid.org/0000-0002-6535-9861)
- Jingjing Li (ORCID: https://orcid.org/0000-0001-8000-7410)
- Yiwen Zhang (ORCID: https://orcid.org/0000-0002-4024-4881)
- Jia Wu
- Hui Zeng (ORCID: https://orcid.org/0000-0002-4498-8888)
- Jiaojiao Ni
- Yu Yao
Institutions
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s10020-025-01125-5
- Citations
- 14
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 13.11
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province