Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA
This study demonstrates the fast degradation of mecciRNAs and the associated regulations of mitochondrial reactive oxygen species release of mitochondrial permeability transition pore by mecciRNAs. HF conditions lead to dysregulated mecciRNA degradation, and exogenous mecciRNAs demonstrate treatment potential in mouse models of HF.
Authors
- X. H. Li (ORCID: https://orcid.org/0000-0001-7969-644X)
- Liang Chen (ORCID: https://orcid.org/0000-0002-2168-5497)
- Yuqi Deng (ORCID: https://orcid.org/0000-0002-9617-2370)
- Ge Shan (ORCID: https://orcid.org/0000-0002-3561-2088)
- Likun Ma (ORCID: https://orcid.org/0000-0002-9680-1472)
- Xu Liu (ORCID: https://orcid.org/0009-0003-9504-4881)
- Peipei Wang
- Xiaolin Wang (ORCID: https://orcid.org/0000-0001-9171-4073)
- Yan Yang (ORCID: https://orcid.org/0000-0001-7075-3428)
- Qinwei Wang (ORCID: https://orcid.org/0000-0002-7542-9851)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1161/circulationaha.124.070840
- Citations
- 17
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 13.70