SRSF4-Associated ca-circFOXP1 Regulates Hypoxia-Induced PASMC Proliferation by the Formation of R Loop With Host Gene
The results demonstrated that the splicing factor SRSF4 upregulated the expression of ca-circFOXP1, and m6A methylation promoted R-loop formation between ca-circFOXP1 and host genes, regulated the level of host protein FOXP1, and then affected the phosphorylation activity of SMAD2, mediating PASMC proliferation, leading to pulmonary vascular remodeling. These results provide a theoretical basis for further study of the pathological mechanisms of hypoxic PH and may provide certain insights.
Authors
- Ya Xu (ORCID: https://orcid.org/0000-0001-9360-8848)
- Xiaodong Zheng (ORCID: https://orcid.org/0000-0002-6103-9836)
- Hanliang Sun
- Cui Ma (ORCID: https://orcid.org/0000-0001-8413-5284)
- Xiaoyu Guan
- Daling Zhu (ORCID: https://orcid.org/0000-0002-6669-2236)
- Jingya Zhang
- Xinyue Song (ORCID: https://orcid.org/0000-0001-8238-309X)
- Xijuan Zhao (ORCID: https://orcid.org/0000-0002-9253-9200)
- Mengnan Li (ORCID: https://orcid.org/0000-0001-7461-3254)
- Lixin Zhang (ORCID: https://orcid.org/0000-0002-6177-4152)
- Huiyu Liu (ORCID: https://orcid.org/0000-0003-4465-8501)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
- X-Fab (Germany) (DE)
- Ministry of Education (KN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1161/atvbaha.124.322026
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03