The histone demethylase dLsd1 regulates organ size by silencing transposable elements

The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death. Mechanistically, we have identified Transposable Elements (TEs) as critical dLsd1 targets for organ size determination. We found that upon dLsd1 loss many TE families are upregulated, and new TE insertions appear. By blocking this new TE activity, we could rescue the wing size phenotype. Collectively, our results reveal that the histone demethylase dLsd1 and maintenance of TE homeostasis are required to ensure proper wing size.

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Publication Details

Journal
Communications Biology
Published
2025-02-20
DOI
https://doi.org/10.1038/s42003-025-07724-6
Citations
2
Primary Topic
Chromosomal and Genetic Variations
Type
article
Field-Weighted Citation Impact
3.50

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article

The histone demethylase dLsd1 regulates organ size by silencing transposable elements

Séverine Chambeyron, Luisa Di Stefano, David L. Cribbs, Bruno Mugat et al.
2 citations
Communications Biology
Chromosomal and Genetic Variations
3.50
article

The histone demethylase dLsd1 regulates organ size by silencing transposable elements

Séverine Chambeyron, Luisa Di Stefano, David L. Cribbs, Bruno Mugat, Manuela Texier, Mourdas Mohamed, Clemèntine Mercé, Inès Selmi, Marion Aguirrenbegoa, Laurence Fraisse-lepourry
article en
2 citations

Abstract

The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death. Mechanistically, we have identified Transposable Elements (TEs) as critical dLsd1 targets for organ size determination. We found that upon dLsd1 loss many TE families are upregulated, and new TE insertions appear. By blocking this new TE activity, we could rescue the wing size phenotype. Collectively, our results reveal that the histone demethylase dLsd1 and maintenance of TE homeostasis are required to ensure proper wing size.

Communications BiologyVol. 8(1)
Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), The Kids Research Institute Australia (AU), Université Fédérale de Toulouse Midi-Pyrénées (FR), Université de Montpellier (FR), Centre de Biologie du Développement (FR), Institut de Génétique Humaine (FR)
Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Ligue Contre le Cancer, Centre National de la Recherche Scientifique, Conseil Régional Midi-Pyrénées
Openalex Percentile: Top 9%
Chromosomal and Genetic Variations
3.50
DOIOpen Access PDFOpenAlex
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The histone demethylase dLsd1 regulates organ size by silencing transposable elements — Séverine Chambeyron, Luisa Di Stefano, et al. · Communications Biology (2025) | TGRS Research Map | TGRS