Tapping Into the Natural PZ-Independent Anticoagulant Function of ZPI to Inhibit Thrombosis With Minimal Effect on Hemostasis
The PZ-binding defective variant of ZPI, D293A, selectively inhibits the intrinsic coagulation pathway and is a new anticoagulant with reduced bleeding risk.
Authors
- Can Wang (ORCID: https://orcid.org/0000-0002-2665-0269)
- Richard Swanson (ORCID: https://orcid.org/0000-0001-9995-9841)
- Xin Huang (ORCID: https://orcid.org/0000-0002-4730-9318)
- Xiaoping Du (ORCID: https://orcid.org/0000-0001-9842-8192)
Institutions
- Illinois College (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1161/atvbaha.124.321329
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 4.88