A Checkpoint Reversal Receptor Mediates Bipartite Activation and Enhances CAR T-cell Function
Enhancing CART function and persistence while balancing immune effector-mediated inflammation is crucial. Using our clinically relevant HER2-CAR platform, we demonstrate that tumor-intrinsic signals like the PD-1/PD-L1 immune checkpoint can be leveraged in CART design to modulate immune synapse and metabolic parameters, improving antitumor function without increasing cytokine production.
Authors
- Kevin Bielamowicz (ORCID: https://orcid.org/0000-0003-0790-2931)
- Purna Krishnamurthy (ORCID: https://orcid.org/0009-0007-4745-2636)
- Lyazat Kurenbekova (ORCID: https://orcid.org/0009-0008-7297-0344)
- Sujith K. Joseph (ORCID: https://orcid.org/0000-0003-4596-1270)
- Raksha R. Bhat (ORCID: https://orcid.org/0000-0002-0026-1118)
- Ahmed Z. Gad (ORCID: https://orcid.org/0000-0002-6149-3414)
- Daniel Landi (ORCID: https://orcid.org/0000-0002-1487-1136)
- Yi Jonathan Zhang (ORCID: https://orcid.org/0000-0002-1364-7175)
- Zeid Nawas (ORCID: https://orcid.org/0000-0001-6603-7664)
- Alesandra S. Echeandia Marrero (ORCID: https://orcid.org/0009-0000-0935-5316)
- Cynthia Chauvin (ORCID: https://orcid.org/0000-0001-6425-8543)
- Michelle Choe (ORCID: https://orcid.org/0000-0001-9850-9435)
- Shoba A. Navai (ORCID: https://orcid.org/0000-0003-1220-2788)
- Pretty R. Matthew
- Nabil Ahmed (ORCID: https://orcid.org/0000-0002-0982-8424)
- Meenakshi Hegde (ORCID: https://orcid.org/0000-0002-7778-7871)
- John Hicks (ORCID: https://orcid.org/0000-0002-1464-3803)
- Tiara T. Byrd (ORCID: https://orcid.org/0000-0002-0272-8041)
- Ankita Shree (ORCID: https://orcid.org/0000-0002-3359-0313)
- Jessica S. Morris (ORCID: https://orcid.org/0000-0002-2026-1297)
- Khaled Sanber (ORCID: https://orcid.org/0000-0002-8927-9786)
- Dolores Mullikin (ORCID: https://orcid.org/0000-0002-9562-0821)
- Vita S. Salsman
- Kristen Fousek (ORCID: https://orcid.org/0000-0002-2307-5000)
- Alexandre F. Carisey (ORCID: https://orcid.org/0000-0003-1326-2205)
- Rebecca M. Brock (ORCID: https://orcid.org/0000-0003-4022-6189)
- Jason T. Yustein (ORCID: https://orcid.org/0000-0002-2052-0527)
- Shuo Xu (ORCID: https://orcid.org/0009-0003-5017-8501)
- Angela M. Major
- Matthew Campbell
- Amr M. Saadeldin (ORCID: https://orcid.org/0000-0002-5971-2083)
Institutions
- Houston Methodist (US)
- Arkansas Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
- Emory University (US)
- Duke University (US)
- Baylor College of Medicine (US)
- Fred Hutch Cancer Center (US)
- Methodist Hospital (US)
- National Cancer Institute (US)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0125
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14