Quantification of [<sup>11</sup>C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations
The scarce availability of cerebellar allosteric binding sites at autoradiography, compared to immunohistochemistry results, might reflect the presence of distinct mGluR5 isoforms or conformational state. Together with our PET data, these data support the proposition that [<sup>11</sup>C]ABP688 BPND using the cerebellum as a reference region provides accurate quantification of mGluR5 allosteric binding in vivo. Studies relying on this method could, therefore, be used in clinical populations, providing that stronger initial assumptions are met.
Authors
- José Eduardo Peixoto-Santos (ORCID: https://orcid.org/0000-0001-7461-1902)
- Eliane Kobayashi (ORCID: https://orcid.org/0000-0002-1713-1563)
- Luciano Minuzzi (ORCID: https://orcid.org/0000-0001-7532-1851)
- Mark Angle
- Jeroen Verhaeghe (ORCID: https://orcid.org/0000-0002-4493-1902)
- Andrew J. Reader (ORCID: https://orcid.org/0000-0002-2726-3383)
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Michele Stanislaw Milella (ORCID: https://orcid.org/0000-0002-5939-8549)
- Chawki Benkelfat
- Marco Leyton (ORCID: https://orcid.org/0000-0002-1243-2252)
- Esther Schirrmacher (ORCID: https://orcid.org/0000-0003-4988-7821)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Alexandre Kirlow
- Marie‐Christine Guiot
- Antonio Aliaga (ORCID: https://orcid.org/0009-0006-9792-7815)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Antwerp (BE)
- University of Alberta (CA)
- King's College London (GB)
- Douglas Mental Health University Institute (CA)
- Policlinico Umberto I (IT)
- McGill University (CA)
- Sapienza University of Rome (IT)
- Universidade Federal de São Paulo (BR)
- McMaster University (CA)
Publication Details
- Journal
- Current Neuropharmacology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.2174/1570159x23666250127161855
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Alzheimer's Association
- Fondation Brain Canada
- Government of Canada
- Health Canada
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé