Intrinsic brain network stability during kainic acid‐induced epileptogenesis
This fMRI study explored how brain connectivity changes in healthy animals compared to animals in the latent period of epilepsy. We found that functional connectivity increased during the latent period compared to the control group, and this increase persisted across all tested sessions. Additionally, brain networks became less stable in the epilepsy group, particularly in the frontal cortex and hippocampus. These observations provide further insight into how brain networks change and persist during the early stages of epileptogenesis.
Authors
- Lingna He
- Anatol Bragin (ORCID: https://orcid.org/0000-0003-1207-8481)
- Nastaran Jafari (ORCID: https://orcid.org/0000-0001-7542-2898)
- Neil G. Harris (ORCID: https://orcid.org/0000-0002-1965-6750)
- Hsiang J. Yeh
- Charbel Khalil (ORCID: https://orcid.org/0000-0001-7740-6963)
- Jerome Engel (ORCID: https://orcid.org/0000-0001-6324-5716)
- John M. Stern (ORCID: https://orcid.org/0000-0002-3549-1642)
- Lin Li (ORCID: https://orcid.org/0000-0002-9996-9377)
Institutions
- University of North Texas (US)
- University of California, Los Angeles (US)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/epi4.70002
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Neurological Disorders and Stroke