Glucocorticoid exposure-induced alterations in epigenetic age from human preterm infants and human lung fibroblasts and hippocampal neuronal cells
Our results identified the cellular and molecular evidences of epigenetic clock changes in neonatal growth and developmental trajectories with the interference of antenatal corticosteroid treatment and provided potential clinical guidance for the future development of noninvasive fetal assessments to identify pregnant women who could benefit from antenatal corticosteroid in a wider gestational age.
Authors
- Hongyu Ni (ORCID: https://orcid.org/0000-0002-7597-2037)
- Cunyou Zhao (ORCID: https://orcid.org/0000-0001-6116-4584)
- Chenglin Lu (ORCID: https://orcid.org/0009-0005-1837-5358)
- Wenbo Xiao (ORCID: https://orcid.org/0000-0001-7124-1096)
- Xiaohui Wu (ORCID: https://orcid.org/0000-0003-1356-3497)
- Deng Zhi-ying
Institutions
- Ministry of Education (RW)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s13148-025-01837-9
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Science and Technology Planning Project of Guangdong Province