Computational Identification and Anti-Inflammatory Evaluation of T19093 as a TLR4/MD2 Inhibitor
T19093 was discovered as a potential novel TLR4/MD2 inhibitor using machine learning and virtual screening techniques and showed potent anti-inflammatory activity, which could provide a new therapeutic alternative for the treatment of inflammation-related diseases.
Authors
- Kuida Chen
- Wu Yin (ORCID: https://orcid.org/0000-0002-5041-0134)
- Jin Tong
- Shipeng Lu (ORCID: https://orcid.org/0000-0002-1817-0417)
- Ke Shi (ORCID: https://orcid.org/0000-0002-8213-3469)
Institutions
- China Pharmaceutical University (CN)
- Northern Jiangsu People's Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-02-20
- DOI
- https://doi.org/10.2174/0115680266345918250212144023
- Citations
- 1
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.39