Synthesis of novel pyrido[2,3-d]pyrimidine derivatives with pharmacological properties

In search for new anti-microbial and anti-mycobacterial agents with novel mechanism of action and enhanced biological profile, a combinatorial library of Schiff bases (7a-e) 2,3-disubstituted-4-thiazolidinone (8a-e) and 2,3-disubstituted-5-methyl-4-thiazolidinone (9a-e) derivatives have been synthesized as new pharmacophores. By applying standard Vilsmeier-Haack reaction condition. The structures of all the newly synthesised compounds were confirmed by their FTIR, 1H NMR, 13C NMR, mass spectral as well as elemental analysis data. All the newly synthesized compounds were screened for non-automated in vitro antimicrobial and anti-mycobacterial activity against selected pathogens. Some of the newly synthesized compounds exhibited excellent antimicrobial activity and said to be the most proficient members of the series compared to standard drugs and for future scope.