A 10-V-Tolerant Dual-Mode Neural Stimulation System With Self-Sustaining Dynamic Supply and Error-Resilient Digital Stimulus Odometer

This article proposes the eight-channel 10-V-tolerant energy-optimizing dual-mode dynamic supplied stimulation (D2S<inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$^{2})$ </tex-math></inline-formula> system for deep brain stimulation (DBS). The proposed D2S2 system can efficiently provide both current-controlled stimulation (CCS) and voltage-controlled stimulation (VCS) with 7-bit resolution, providing flexibility in stimulation modes. The system adopts the self-sustaining dynamic supply (SSDS) technique, which can be applied to multi-channel simultaneous stimulation, achieving stimulation efficiency of up to 74.8%. The proposed digital error-resilient stimulus odometer (ERSO) with the deglitching capacitor precisely balances the biphasic charge transfer while achieving energy savings of up to 83.6% in VCS. The stimulation channels of the proposed D2S2 system can simultaneously deliver stimuli with dynamic supplies while ensuring 10-V stimulation compliance only with 5-V transistors. In vivo animal experiments on a rat with the D2S2 system fabricated in 0.25-<inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu $ </tex-math></inline-formula>m CMOS process verified the effectiveness of the D2S2 system in halting epileptic seizures.