Current Diagnosis and Management of Gastric Acid Related Diseases: Questionnaire-based Clinical Insights from Indian Experts

The prevalence of gastric acid-related diseases in India is significant, with PPIs being the primary treatment option. We gathered questionnaire-based insights to explore the diagnosis and management of gastric acid-related diseases in India. The responses were received from 103 gastroenterologists from India, which revealed that while PPIs are widely prescribed, there are significant unmet needs such as nocturnal acid breakthrough, slow achievement of maximal effect and food dependent-dosing. With PPIs, patient compliance rates are hardly optimal, and about 20% of patients exhibit PPI resistance. Vonoprazan has shown superior efficacy in management of various diseases under the umbrella of gastric acid-related diseases such as H. pylori eradication and healing erosive esophagitis compared to PPIs. The majority of respondents were eager to adopt Vonoprazan and anticipated its positive impact on treatment outcomes. This shift towards PCABs represents a significant advancement in managing these disorders in India, promising better patient compliance and therapeutic success.