A General-Purpose Simulation Platform for Multicellular Molecular Communication Systems

This paper presents the design, implementation, and evaluation of a general-purpose simulation platform for multicellular molecular communication systems. Built on an agent-based model, the platform offers flexibility to simulate diverse multicellular systems, such as cancer spheroids and vascular-like networks. It incorporates efficient algorithms, including Cell-List and Barnes-Hut, for calculating cell-cell interaction forces and supports dynamic behaviors such as cell division, growth, and death. The platform’s capabilities are demonstrated through use cases, highlighting its versatility and coding efficiency. The simulation platform serves as a valuable tool for advancing research in molecular communication and understanding the collective behavior of complex multicellular systems.