Brain Metabolic Features of <i>FUS</i>‐<scp>ALS</scp>: A 2‐[<scp><sup>18</sup>F</scp>]<scp>FDG</scp>‐<scp>PET</scp> Study
Patients with FUS-ALS show relative preservation of motor cortex metabolism compared with those with sALS, possibly reflecting the prevalence of lower motor neuron impairment in their phenotype. Prospective studies are necessary to investigate the possible role of 2-[<sup>18</sup>F]FDG-PET as a biomarker to track disease spreading in clinical trials. ANN NEUROL 2025;97:1134-1143.
Authors
- Paolina Salamone (ORCID: https://orcid.org/0000-0001-9038-7816)
- Antonio Canosa (ORCID: https://orcid.org/0000-0001-5876-4079)
- Giulia Marchese
- Salvatore Gallone (ORCID: https://orcid.org/0000-0002-3156-4613)
- Grazia Zocco
- Enrico Matteoni (ORCID: https://orcid.org/0009-0008-2963-8821)
- Andrea Calvo (ORCID: https://orcid.org/0000-0002-5122-7243)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Giulia Polverari (ORCID: https://orcid.org/0000-0002-5192-7282)
- Luca Sbaiz
- Sara Cabras (ORCID: https://orcid.org/0000-0002-4988-2855)
- Maurizio Grassano (ORCID: https://orcid.org/0000-0001-6714-6897)
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Filippo De Mattei
- Francesca Palumbo (ORCID: https://orcid.org/0000-0002-7070-2409)
- Cristina Moglia (ORCID: https://orcid.org/0000-0001-7377-7222)
- Francesca Di Pede (ORCID: https://orcid.org/0000-0001-8959-0614)
- Adriano Chiò (ORCID: https://orcid.org/0000-0001-9579-5341)
- Marco Pagani (ORCID: https://orcid.org/0000-0003-4689-0750)
- Federico Casale (ORCID: https://orcid.org/0000-0002-1097-1279)
- Giuseppe Fuda
- Giovanni De Marco
- Maura Brunetti
- Emilio Minerva
Institutions
- Università di Camerino (IT)
- Karolinska University Hospital (SE)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Neuroscience Institute (IT)
- Institute of Cognitive Sciences and Technologies (IT)
- University of Turin (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/ana.27201
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Torino
- Ministero dell'Università e della Ricerca
- Horizon 2020 Framework Programme