Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer—An Expert Survey
<b>Background/Objectives</b>: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. <b>Methods</b>: We conducted a cross-sectional survey from May to July 2023 involving expert centers identified through their scientific contributions and participation in international workgroups and conferences.. The survey, comprising 27 questions, evaluated existing practices in FSS. <b>Results</b>: Out of the centers surveyed, 21 (36.2%) gynecologic oncologists responded. For tumors <2 cm, 86% of centers preferred radical trachelectomy, primarily via the vaginal approach, while 13.6% favored a simple trachelectomy. Three experts preferred simple trachelectomy (13.6%). For tumors >2 cm, 47.6% utilized neoadjuvant chemotherapy before trachelectomy. Others did not offer FSS or performed an abdominal radical trachelectomy. Over time, there has been a shift towards less radical surgeries for tumors <2 cm and increased use of neoadjuvant chemotherapy for larger tumors. Some abandoned the minimally invasive surgical approach. Nearly all experts (90.5%) placed a cerclage immediately following trachelectomy. <b>Conclusions</b>: The majority of experts opt for radical trachelectomy in early stage cervical cancer, with immediate cerclage placement being a common practice. However, considerable international variations highlight the urgent need for standardized guidelines and further research to optimize treatment strategies, balancing oncological safety with fertility outcomes.
Authors
- Peter Hillemanns (ORCID: https://orcid.org/0000-0001-9829-3531)
- Nadeem R. Abu‐Rustum (ORCID: https://orcid.org/0000-0001-9689-1298)
- Glauco Baiocchi (ORCID: https://orcid.org/0000-0002-8193-5582)
- Luc R.C.W. van Lonkhuijzen (ORCID: https://orcid.org/0000-0001-6905-2704)
- Reitan Ribeiro (ORCID: https://orcid.org/0000-0002-4323-3854)
- Cornelis G. Gerestein (ORCID: https://orcid.org/0000-0003-0490-2258)
- Joo‐Hyun Nam (ORCID: https://orcid.org/0000-0001-8300-6974)
- Maaike A. van der Aa (ORCID: https://orcid.org/0000-0002-2934-2704)
- Jan Persson (ORCID: https://orcid.org/0000-0001-5642-2497)
- Karlijn Cornel (ORCID: https://orcid.org/0000-0001-8544-0790)
- Denis Querleu (ORCID: https://orcid.org/0000-0002-3984-4812)
- Ali Kucukmetin
- Philippe Morice (ORCID: https://orcid.org/0000-0003-0579-9993)
- Jogchum Beltman (ORCID: https://orcid.org/0000-0002-0048-7360)
- Allan Covens (ORCID: https://orcid.org/0000-0001-7958-8502)
- Anke B. Smits (ORCID: https://orcid.org/0000-0002-7484-4244)
- Mieke Ten Eikelder (ORCID: https://orcid.org/0000-0001-8846-0631)
- Petra L.M. Zusterzeel (ORCID: https://orcid.org/0000-0001-9547-6367)
- Myriam Perrotta (ORCID: https://orcid.org/0000-0001-6134-3419)
- Blanca Gil‐Ibáñez (ORCID: https://orcid.org/0000-0002-0361-8741)
- Marie Plante (ORCID: https://orcid.org/0000-0002-2298-7913)
- Henrik Falconer (ORCID: https://orcid.org/0000-0003-4427-9421)
- Janneke T. Wolswinkel
- Christhardt Köhler (ORCID: https://orcid.org/0000-0002-0049-6398)
- Christina Fotopoulou (ORCID: https://orcid.org/0009-0008-1672-2901)
- László Ungár
Institutions
- Ulsan College (KR)
- Memorial Sloan Kettering Cancer Center (US)
- Karolinska University Hospital (SE)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- University of Toronto (CA)
- Lund University (SE)
- Utrecht University (NL)
- Université Paris-Saclay (FR)
- Leiden University Medical Center (NL)
- Buda Health Center (HU)
- Asan Medical Center (KR)
- Institut Gustave Roussy (FR)
- Hospital Italiano de Buenos Aires (AR)
- Agostino Gemelli University Polyclinic (IT)
- Princess Margaret Cancer Centre (CA)
- Radboud University Medical Center (NL)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- AC Camargo Hospital (BR)
- Medizinische Hochschule Hannover (DE)
- University of Ulsan (KR)
- Asklepios Klinik Altona (DE)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Erasto Gaertner (BR)
- Queen Elizabeth Hospital (GB)
- DRK Kliniken Berlin (DE)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- Université Laval (CA)
- Cancer Center Amsterdam (NL)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Personalized Medicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3390/jpm15030077
- Citations
- 4
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.23