Metabolic engineering of Komagataella phaffii for enhanced 3-hydroxypropionic acid (3-HP) production from methanol
Our results point out the potential of lactate transporters to efficiently drive 3-HP export in K. phaffii, leading to higher titers, yields, and productivities, even at lower pH conditions.
Authors
- Pau Ferrer (ORCID: https://orcid.org/0000-0002-5287-4127)
- Joan Albiol (ORCID: https://orcid.org/0000-0001-5626-429X)
- Sílvia Àvila-Cabré (ORCID: https://orcid.org/0000-0001-6179-4877)
Institutions
- Universitat Autònoma de Barcelona (ES)
Publication Details
- Journal
- Journal of Biological Engineering
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s13036-025-00488-x
- Citations
- 7
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- European Commission
- Agència de Gestió d'Ajuts Universitaris i de Recerca