Associations of Plasma Neurofilament Light Levels With Brain Microstructure and Macrostructure and Cognition in the Community-Based Rhineland Study
Higher plasma NfL levels mainly reflect worse white matter microstructural integrity, especially lower axonal density, in a relatively healthy, community-based sample. This suggests that plasma NfL levels allow for early detection of subtle differences in brain microstructure.
Authors
- Marina L. S. Santos
- Meta M. Boenniger (ORCID: https://orcid.org/0000-0003-4134-980X)
- Alexandra Koch (ORCID: https://orcid.org/0000-0002-9795-0541)
- Ulrich Ettinger (ORCID: https://orcid.org/0000-0002-0160-0281)
- N. Ahmad Aziz (ORCID: https://orcid.org/0000-0001-6184-458X)
- Monique M.B. Breteler (ORCID: https://orcid.org/0000-0002-0626-9305)
- Valerie Lohner (ORCID: https://orcid.org/0000-0001-5589-9701)
- Annabell Coors (ORCID: https://orcid.org/0000-0001-9000-6390)
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- German Center for Neurodegenerative Diseases (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- University Hospital Cologne (DE)
- Columbia University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1212/wnl.0000000000210278
- Citations
- 3
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08