Photoredox/Copper Dual-Catalyzed Three-Component Perfluoroalkyl Trifluoromethylthiolation of Alkenes
A new three-component 1,2-perfluoroalkyl trifluoromethylthiolation of alkenes via dual photoredox/copper catalysis has been established, affording a variety of C<sub><i>n</i></sub>F<sub>2<i>n</i>+1</sub>/CF<sub>3</sub>S-containing molecules under mild conditions in a redox-neutral manner. This protocol exhibits excellent functional group tolerance, broad compatibility with various alkenes and perfluoroalkyl iodides, and potential utility in the modification of bioactive molecules.
Authors
- Yutong Yang
- Shaomian Liu (ORCID: https://orcid.org/0009-0004-3325-3167)
- Kang Guo (ORCID: https://orcid.org/0009-0005-7316-502X)
- Aijun Song (ORCID: https://orcid.org/0000-0002-0319-466X)
- Yongchao Lu (ORCID: https://orcid.org/0000-0002-6924-181X)
- Xu Fang (ORCID: https://orcid.org/0000-0002-3900-1065)
- Jiayi Shang
Institutions
- Hebei Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c00289
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.74
Funders
- Department of Education of Hebei Province