Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways
Taken together, these findings demonstrate that <i>Lyc.HCL</i> can effectively suppress ESCC both in vitro and in vivo by targeting TRIM22 and regulating the JAK2/STAT3 and Erk pathways. These results suggest that <i>Lyc.HCL</i> may serve as a potential novel therapeutic for ESCC, with TRIM22 emerging as a promising target for treatment.
Authors
- Liangxian Qiu (ORCID: https://orcid.org/0009-0007-7485-8631)
- Tao Zeng (ORCID: https://orcid.org/0000-0001-8896-0361)
- Jialing Chen (ORCID: https://orcid.org/0000-0001-5186-3488)
- Jingyan Liu (ORCID: https://orcid.org/0000-0002-8683-1504)
Institutions
- Guangdong Medical College (CN)
- Peking University Shenzhen Hospital (CN)
Publication Details
- Journal
- Cancers
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3390/cancers17050718
- Citations
- 4
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 6.23