Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population
Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development and progression are poorly understood. We used ICD codes and a natural language processing algorithm to identify individuals in a hospital biobank with SI-only, SB, and controls without either. We compared the profiles of SB and SI-only patients to controls, and each other, using phenome-wide association studies (PheWAS) and polygenic risk scores (PRS). PheWAS identified many risk factors for SB and SI-only, plus specific psychiatric disorders which may be involved in progression from SI-only to SB. PRS for suicide attempt were only associated with SB, and even after accounting for psychiatric disorder PRS. SI PRS were only associated with SI-only, although not after accounting for psychiatric disorder PRS. These findings advance understanding of distinct genetic and clinical risk factors for SB and SI-only, which will aid in early detection and intervention efforts.
Authors
- Chikashi C. Terao (ORCID: https://orcid.org/0000-0002-6452-4095)
- Nakao Iwata (ORCID: https://orcid.org/0000-0003-3189-6076)
- Lauren Lepow (ORCID: https://orcid.org/0000-0002-1919-6897)
- Jyotishman Pathak (ORCID: https://orcid.org/0000-0002-4856-410X)
- Michael Preuß (ORCID: https://orcid.org/0000-0001-5266-8465)
- Masashi Ikeda (ORCID: https://orcid.org/0000-0001-6237-2449)
- Brian Fennessy (ORCID: https://orcid.org/0000-0002-6222-6190)
- Niamh Mullins (ORCID: https://orcid.org/0000-0001-8021-839X)
- Sarah M. C. Colbert (ORCID: https://orcid.org/0000-0003-3060-7471)
- J. John Mann
- Hilary Coon (ORCID: https://orcid.org/0000-0002-8877-5446)
- Takeo Saito (ORCID: https://orcid.org/0000-0003-3671-4585)
Institutions
- Fujita Health University (JP)
- University of Shizuoka (JP)
- Cornell University (US)
- University of Utah (US)
- Columbia University Irving Medical Center (US)
- Huntsman Cancer Institute (US)
- New York Psychoanalytic Society and Institute (US)
- Presbyterian Hospital (US)
- Shizuoka General Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Weill Cornell Medicine (US)
- New York State Psychiatric Institute
- Nagoya University (JP)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1038/s41398-025-03287-6
- Citations
- 5
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.53
Funders
- National Science Foundation
- Brain and Behavior Research Foundation
- Japan Agency for Medical Research and Development
- National Alliance for Research on Schizophrenia and Depression
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Institute of Mental Health
- National Center for Advancing Translational Sciences