Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism
Our findings suggest metabolomic changes primarily involving different lipid classes and carnitine metabolism may underscore ALS severity and progression. ANN NEUROL 2025;98:19-34.
Authors
- Kai Guo (ORCID: https://orcid.org/0000-0002-4651-781X)
- Masha G. Savelieff (ORCID: https://orcid.org/0000-0001-5575-2494)
- Dae‐Gyu Jang (ORCID: https://orcid.org/0009-0009-7966-1322)
- Eva L. Feldman (ORCID: https://orcid.org/0000-0002-9162-2694)
- Samuel J. Teener (ORCID: https://orcid.org/0009-0003-9072-8184)
- Junguk Hur (ORCID: https://orcid.org/0000-0002-0736-2149)
- Lili Zhao (ORCID: https://orcid.org/0000-0002-6366-8206)
- Stephen A. Goutman (ORCID: https://orcid.org/0000-0001-8780-6637)
Institutions
- University of North Dakota (US)
- University of Michigan (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/ana.27208
- Citations
- 11
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 15.28
Funders
- A. Alfred Taubman Medical Research Institute
- Sinai Medical Staff Foundation
- National Institutes of Health
- Centers for Disease Control and Prevention
- Michigan Institute for Clinical and Health Research
- National Institute of Neurological Disorders and Stroke
- National Institute of Environmental Health Sciences
- National Center for Advancing Translational Sciences