A Multicenter Study of Hereditary Transthyretin Amyloidosis in China
This study highlights that ATTRv patients in China exhibit high heterogeneity in their initial symptoms. The most common variants observed in this cohort is Val30Met. The mtDNA copy number shows gender-linked effects. These results can impact ATTRv diagnosis and patient care strategies. ANN NEUROL 2025;97:1158-1167.
Authors
- Juan Kang (ORCID: https://orcid.org/0000-0001-9584-6700)
- Haishan Jiang (ORCID: https://orcid.org/0000-0002-7388-8659)
- Bin Chen (ORCID: https://orcid.org/0000-0001-8370-9346)
- Xujun Chu (ORCID: https://orcid.org/0000-0002-6497-1979)
- Min Qian (ORCID: https://orcid.org/0000-0002-8622-1773)
- Li Hua Cao (ORCID: https://orcid.org/0000-0003-1742-9877)
- Xinghua Luan (ORCID: https://orcid.org/0000-0001-6683-5105)
- Zaiqiang Zhang (ORCID: https://orcid.org/0000-0002-0053-3451)
- Daojun Hong (ORCID: https://orcid.org/0000-0003-1380-3534)
- Zhi‐Ying Wu (ORCID: https://orcid.org/0000-0003-2106-572X)
- Yuwei Da
- Jingwen Xu (ORCID: https://orcid.org/0000-0002-2451-8037)
- Min Zhu (ORCID: https://orcid.org/0000-0002-7468-0083)
- Tao Huang (ORCID: https://orcid.org/0000-0002-0328-1368)
- Zhang‐Yu Zou
- Jie Lin (ORCID: https://orcid.org/0000-0003-2364-7993)
- Yun Yuan (ORCID: https://orcid.org/0000-0003-3282-9123)
- Kang Du (ORCID: https://orcid.org/0000-0002-3088-8552)
- Wei Li (ORCID: https://orcid.org/0009-0003-4681-4923)
- Jia Li (ORCID: https://orcid.org/0000-0003-1500-869X)
- Lingchao Meng
- Xiaoxuan Liu (ORCID: https://orcid.org/0000-0003-4021-8744)
- Zhaoxia Wang (ORCID: https://orcid.org/0000-0002-8723-4242)
- Chong Sun (ORCID: https://orcid.org/0000-0001-5933-0467)
- Hao Yu (ORCID: https://orcid.org/0009-0006-4768-0025)
- Meihong Zhou
- Dongsheng Fan (ORCID: https://orcid.org/0000-0002-6679-0864)
- Qingping Wang
Institutions
- Fujian Medical University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Central South University (CN)
- Nanchang University (CN)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Fudan University (CN)
- Kunming Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Nanfang Hospital (CN)
- Qujing Normal University (CN)
- Peking University First Hospital (CN)
- Peking University Third Hospital (CN)
- Xi’an Children’s Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huashan Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Qilu Hospital of Shandong University (CN)
- Union Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/ana.27203
- Citations
- 7
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Peking University First Hospital
- Peking University