BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression
Therapeutic strategies aimed at harnessing anti-tumor immunity are being intensively investigated as they show promising results in cancer treatment. The PD-1/ PD-L1 pathway is an essential target for restoring functional anti-tumor immune response. BRD7 is a candidate tumor suppressor gene and nuclear transcription factor of nasopharyngeal carcinoma (NPC) which was cloned in our laboratory. In this paper, we reported that the candidate tumor suppressor gene BRD7 was strongly associated with good prognosis of NPC patients and negatively regulated PD-L1 expression. In addition, we found that BRD7 down-regulated PD-L1 expression and enhanced the killing function of CD8<sup>+</sup> T lymphocytes in NPC cells through binding to p85α via the 485-651 domain and inhibiting the activity of PI3K, thereby inhibiting the activity of PI3K/AKT/mTOR/STAT3 pathway. <i>In vivo</i> experiments, the results showed that BRD7 could not only inhibit the growth of tumors, but also play a better anti-tumor effect when combined with PD-L1 antibody. These results provided further evidence that BRD7 inhibited immune escape of NPC through down-regulating PD-L1 expression.
Authors
- Qing Zhou (ORCID: https://orcid.org/0000-0002-0281-3916)
- Ying Liu (ORCID: https://orcid.org/0000-0001-5834-6934)
- Xiaoxu Li (ORCID: https://orcid.org/0000-0001-6448-7581)
- Zhaoyang Zeng
- Ziying Tian (ORCID: https://orcid.org/0009-0002-9131-6053)
- Jieyu Zhou (ORCID: https://orcid.org/0000-0002-8729-3568)
- Ming Zhou (ORCID: https://orcid.org/0000-0002-7460-550X)
- Mengna Li (ORCID: https://orcid.org/0000-0001-7081-135X)
- Nan Li (ORCID: https://orcid.org/0000-0003-1179-0063)
- Su Jiang (ORCID: https://orcid.org/0009-0006-1030-5096)
- Shiqi Yan
- Yilin Guo (ORCID: https://orcid.org/0009-0007-8410-2328)
- Donghai Huang (ORCID: https://orcid.org/0000-0002-8905-3234)
- Xiao Zhou (ORCID: https://orcid.org/0000-0002-6155-7860)
- Guiyuan Li
- Xiayu Li
- Songqing Fan
- Wei Xiong (ORCID: https://orcid.org/0000-0002-5645-1631)
- Lei Shi (ORCID: https://orcid.org/0000-0002-7438-2318)
- Jiaxue Lu
- Wenling Zhang (ORCID: https://orcid.org/0000-0003-2674-7092)
Institutions
- Central South University (CN)
- Ministry of Education (SA)
- Zhengzhou City Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- International Journal of Biological Sciences
- Published
- 2025-02-10
- DOI
- https://doi.org/10.7150/ijbs.103703
- Citations
- 6
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 6.27