Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Systemic Lupus Erythematosus via Glucose Metabolism of CD4+T Cells
hUC-MSCs inhibited the proliferation and function of aberrant CD4<sup>+</sup> T cells in SLE patients by modulating glycometabolism and the JAK-STAT and PI3K-Akt signaling pathways, providing new insights into the therapeutic mechanisms of MSCs based on metabolic reprogramming.
Authors
- Jin Lu (ORCID: https://orcid.org/0000-0002-0946-3357)
- Hongtao Jin (ORCID: https://orcid.org/0000-0002-0638-707X)
- Aijing Liu (ORCID: https://orcid.org/0000-0002-5762-5592)
- Jun Ma (ORCID: https://orcid.org/0000-0003-2843-0769)
- Shaoxin Cui
- Meng Ding
- Jingjing He (ORCID: https://orcid.org/0000-0001-5574-1517)
- Qun Wang (ORCID: https://orcid.org/0000-0001-7929-7692)
- Xue Liu (ORCID: https://orcid.org/0000-0002-2104-9335)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0001-6265-530X)
- Min Shi (ORCID: https://orcid.org/0000-0002-2130-181X)
- Fei Chang (ORCID: https://orcid.org/0000-0003-1155-1003)
- Jingjing Yu (ORCID: https://orcid.org/0000-0002-2408-5809)
- Lin Yang (ORCID: https://orcid.org/0000-0001-5383-4779)
- Shuran Song
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Stem Cell Reviews and Reports
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1007/s12015-025-10848-1
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology
- Hebei Medical University